Rett Syndrome

Rett syndrome is a neurodevelopmental disorder that almost exclusively affects girls. Children with Rett’s syndrome, in the initial stages, tend to show symptoms that are very much similar to early signs of autism. Much like autism, your child shows normal growth and development followed by a gradual (or sudden) regression of their developmental skills. Most children diagnosed with Rett Syndrome will have slower head and brain growth which is often an early indication of the disorder. Seizures are quite common as well.

rett syndrome

Rett’s Syndrome is perhaps the rarest among the major types of Autism and perhaps the only one that could be confirmed through medical tests. The support level required for girls with Rett’s syndrome ranges from Level 2 to Level 3. Jump to the end of the post for the various support levels across the Autism Spectrum Disorder.

A Quick Look @ Rett’s Syndrome

Rett’s Syndrome has no racial or ethnic relationship. It is estimated that only one in every 10,000 female births will produce a female with Rett’s syndrome.


Newborns would be diagnosed with Autism in near future


Of all children diagnosed for ASD will be girls


Of Girls would be diagnosed +ve for Rett’s Syndrome

Causes of Rett Syndrome

Unlike autism (which may only have a genetic predisposition, refer to the article on Is Autism Genetic), Rett’s syndrome is considered a genetic disorder though it is surprising that in most cases, it occurs in families without any prior history of autism. Rett’s is caused when a mutation randomly occurs in a gene. Only one percent of the recorded cases are said to be inherited which means that the rest of the cases are caused due to spontaneous and random mutations.

Rett Syndrome is caused by the mutation of MECP2 gene. This allows for genetic testing prior to birth, thereby reducing the risk of a family having more than one child with Rett’s Syndrome to less than one percent (except for twins).

Fig 1: Symptoms of Rett Syndrome in 2 Girls

Fig 1: Symptoms of Rett’s Syndrome in 2 Girls

Role of MECP2 Gene

Fig 2: Role of MECP2 Gene

Rett’s Syndrome – Why Only Girls?

the role of X & Y in Rett Syndrome

Fig 3: The role of X & Y in Rett Syndrome

It is important to note that MECP2 gene is a component of the X chromosome. Since girls possess two X chromosomes, this results in higher risk for Rett’s syndrome. Due to the result of this mutation, out of the two X chromosomes that girls have, only one remains active in each cell. This means that girls with Rett’s syndrome only use a portion are missing the functionality of the other X chromosome, hence the impairment. But still, since the other X is fully functional, the core metabolic and neuro-functional requirements are still met and the girl survives.

But the situation is different when it comes to boys. Boys only have one X chromosome, and therefore lack a backup that could compensate for a defective one. Since they lack any form protection from MECP2 mutations and often die shortly after birth. The small and infrequent numbers of boys that do manage to make it usually suffer a far greater degree of intellectual ability.

The Stages of Rett Syndrome

There are four (4) key stages of Rett Syndrome. Prior to the onset of symptoms your child tends to grow and develop normally. Gradually mental and physical symptoms start to appear. Early symptoms may include sensory issues like problems with crawling, walking and eye contact, all of which were initially present, but are now regressing (read at what age is autism usually diagnosed). There is also a loss in use of the hands followed by compulsive hand movements.

Stages of Rett Syndrome in Girls

Fig 4: Stages of Rett Syndrome in Girls

Rett’s Syndrome Therapy and Treatment Options

Like many other neurological problems, there is no cure for Rett Syndrome. Treatment is generally tactical and based on the symptoms that appear. Most of the time, the focus is on managing the symptoms, especially the sleep apnea symptoms. There is medication to assist with breathing and seizures.

Beat Rett Syndrome
It is important for parents and caregivers to monitor for scoliosis and possible heart problems. You should have regular visits with your physician to allow for early diagnosis of any of these problems. Occupational therapy for autism and the use of leg or hand braces can be of value in helping your child be more independent. Much like autism, assistance with academics, speech, and social interaction is always advised.

Here is what Dr. Ronin Steward had to say about Rett’s:

Rett Syndrome is RARE, but for parents of a child with Rett Syndrome there is hope! Despite the difficulties with symptoms, many individuals with Rett syndrome continue to live well into middle age and beyond.  Because the disorder is rare, very little is known about long-term prognosis and life expectancy.  While there are women in their 40s and 50s with the disorder, currently it is not possible to make reliable estimates about life expectancy beyond age 40.
Ronin Steward, Autism Research Institute

Children on the autism spectrum have occupational, behavioral, speech and various other therapies available to them. These same therapies are available to children with Rett Syndrome. Physical therapists, who can provide braces for steadier mobility and function, work daily with children with Rett syndrome. Water therapy is highly recommended for girls with Rett Syndrome as it keeps the muscles free and mobile in a controlled manner.

Reference: Support Level Classification of Autism Types

There are primarily 3 Levels of Support for people with ASD. Click on the Support Levels in the table below to know what they mean. Also, you can click on the Autism Types at the header to acquire an understanding of what each type of autism means.

Autism Forms Support Level Classical Autism Asperger’s PDD-NOS Rett’s Syndrome CDD
Mild Autism Level 1
Moderate Autism Level 2
Severe Autism Level 3
2016-10-19T10:15:40+00:00 December 5th, 2014|Categories: UNDERSTANDING AUTISM|Tags: , |0 Comments

Leave A Comment

The #1 Autism Parenting Magazine
Someone you know has Autism?
2017 (C) All rights reserved.
Thankfully, you have AutisMag!
Thanks! Are you Ready?
Thanks for your interest! Click the button below to download our latest Issue # 33 of AUTISMAG. I bet you will Love this one :-)
Are You Ready?
Thanks for registering to this Free 7 Days Autism Potty Training Email course.

Please check your Inbox from me (Ash Bernard) for your Starter Guide!
Download this 35 Page Detailed PDF Guide that contains:
  • Things to keep in mind while Teaching
  • 11 HIGHLY Effective Teaching Strategies
  • Free Teaching Resources
  • 121 PECS Cards